Inflammation of the tibiofemoral joint: inflammatory mediators, treatment, and long-term effects

I am pleased to highlight the topic of “Inflammation of the Tibiofemoral Joint: Inflammatory Mediators, Treatment, and Long-Term Effects” in Annals of Joint (AOJ). Inflammation within the tibiofemoral joint presents a complex challenge in orthopedics, particularly in the context of inflammatory mediators and development of post-traumatic osteoarthritis (PTOA). The primary goal of this series was threefold: to elucidate common inflammatory mediators in knee joint inflammation, to assess the impact of anti-inflammatory treatments on markers of inflammation, and to evaluate the ramifications of such treatments on tissue healing in knee joint pathologies.

Collectively, this series aims to provide a comprehensive overview of the intricate interplay between inflammation, treatment modalities, and long-term tissue healing outcomes in tibiofemoral joint pathologies. By shedding light on these crucial aspects, this series may contribute to preventive strategies in managing PTOA and change current clinical practice regimens for treating knee joint inflammation using existing non-steroidal anti-inflammatory drugs (NSAIDs). Our expert contributing authors shed light on the controversy of the use of different NSAIDs in the post-surgical setting and their impact on healing of soft tissue and bone.

Acknowledgments

Thank you to all of the authors and co-authors for their time and efforts in contributing to this series. To the Annals of Joint, thank you for highlighting this important topic.

Funding: None.

Footnote

Provenance and Peer Review: This article was commissioned by the editorial office, Annals of Joint for the series “Inflammation of the Tibiofemoral Joint: Inflammatory Mediators, Treatment, and Long-Term Effects”. The article did not undergo external peer review.

Conflicts of Interest: The author has completed the ICMJE uniform disclosure form (available at https://aoj.amegroups.org/article/view/10.21037/aoj-24-13/coif). The series “Inflammation of the Tibiofemoral Joint: Inflammatory Mediators, Treatment, and Long-Term Effects” was commissioned by the editorial office without any funding or sponsorship. N.N.D. served as the unpaid Guest Editor of the series and serves as an unpaid editorial board member of Annals of Joint from August 2022 to July 2024. The author has no other conflicts of interest to declare.

Ethical Statement: The author is accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

Nicholas N. DePhillipo