Early knee osteoarthritis—definition, pathogenesis, diagnosis, treatment, and prevention

Between 2015 and 2050, the World Health Organization (WHO) estimates that the proportion of the world’s population over 60 years will become nearly double from 12% to 22%. WHO also proposes that osteoarthritis (OA) is one of the most significant causes of disability, emphasizing the requirement of comprehensive public health action on the fundamental shift for ageing and health. Knee OA (KOA) is one of the main problems for the aged-society in terms of incidence, impairment in the quality of daily living (QOL), and economics.